Our research is devoted to the understanding of protein sorting in various intracellular transport pathways, including entry into cells by endocytosis, post-Golgi trafficking and transport to lysosomes, as well as biogenesis and turnover of lipid droplets.

Using biochemical assays on isolated proteins or vesicles, in combination with cell-based functional assays and together with structural analysis, we gain mechanistic insight into the function and regulation of the intracellular sorting machinery.

This is key to the understanding of a growing number of human diseases including atherosclerosis, hypopigmentation, various forms of inherited mental retardation, the Hermansky-Pudlak-Syndrome, or diverse lysosomal storage diseases.