Our work focuses on the role of inflammation and tissue homeostasis in pathophysiological diseases. Especially we work on the consequences of derailed cell cycle as a driver of inflammation and the role of different inflammatory molecules in regulating the cell cycle itself. As a consequence of abnormal division, cells will engage in a variety of different cell death modalities that shape tissue microenvironment, regulate tissue damage and will activate an immune response impacting development as well as contribute to many inflammatory conditions.