Publikationen
Veröffentlichte Artikel und Reviews (die Titel der drei wichtigsten Veröffentlichungen sind hervorgehoben)
Nicastro R*, Brohée L*, Alba J, Nüchel J, Figlia G, Kipschull S, Gollwitzer P, Romero-Pozuelo J, Fernandes SA, Lamprakis A, Vanni S, Teleman AA, De Virgilio C, Demetriades C. Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor. Nature Cell Biology 2023 Aug 10.
Sen A, Kallabis S, Gaedke F, Jüngst C, Boix J, Nüchel J, Maliphol K, Hofmann J, Schauss AC, Krüger M, Wiesner RJ, Pla-Martín D. Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA. Nature Communications. 2022 Nov 7;13(1):6704.
Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA. Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metabolism. 2021 Dec 7;33(12):2398-2414.e9.
Demetriades C, Nüchel J, Plomann M. GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome. Cell Stress. 2021 Oct 15;5(11):173-175.
Pothukuchi P, Agliarulo I, Pirozzi M, Rizzo R, Russo D, Turacchio G, Nüchel J, Yang JS, Gehin C, Capolupo L, Hernandez-Corbacho MJ, Biswas A, Vanacore G, Dathan N, Nitta T, Henklein P, Thattai M, Inokuchi JI, Hsu VW, Plomann M, Obeid LM, Hannun YA, Luini A, D'Angelo G, Parashuraman S. GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis. The EMBO Journal. 2021 Oct 18;40(20):e107766.
Nüchel J, Tauber M, Nolte JL, Mörgelin M, Türk C, Eckes B, Demetriades C, Plomann M. An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Molecular Cell. 2021 Aug 19;81(16):3275-3293.e12.
Zehender A, Li YN, Lin NY, Stefanica A, Nüchel J, Chen CW, Hsu HH, Zhu H, Ding X, Huang J, Shen L, Györfi AH, Soare A, Rauber S, Bergmann C, Ramming A, Plomann M, Eckes B, Schett G, Distler JHW. TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy. Nature Communications. 2021 Jul 20;12(1):4404.
Malinova TS, Angulo-Urarte A, Nüchel J, Tauber M, van der Stoel MM, Janssen V, de Haan A, Groenen AG, Tebbens M, Graupera M, Plomann M, Huveneers S. A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. Nature Communications. 2021 May 10;12(1):2610.
Auler M, Bergmeier V, Georgieva VS, Pitzler L, Frie C, Nüchel J, Eckes B, Hinz B, & Brachvogel B. miR-127-3p Is an Epigenetic Activator of Myofibroblast Senescence Situated within the MicroRNA-Enriched Dlk1-Dio3‒Imprinted Domain on Mouse Chromosome 12. The Journal of Investigative Dermatology. 2021 Apr;141(4S):1076-1086.e3.
van Dijk FS, Semler O, Etich J, Köhler A, Jimenez-Estrada JA, Bravenboer N, Claeys L, Riesebos E, Gegic S, Piersma SR, Jimenez CR, Waisfisz Q, Flores CL, Nevado J, Harsevoort AJ, Janus GJM, Franken AAM, van der Sar AM, Meijers-Heijboer H, Heath KE, Lapunzina P, Nikkels PGJ, Santen GWE, Nüchel J, Plomann M, Wagener R, Rehberg M, Hoyer-Kuhn H, Eekhoff EMW, Pals G, Mörgelin M, Newstead S, Wilson BT, Ruiz-Perez VL, Maugeri A, Netzer C, Zaucke F, Micha D. Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2. American Journal of Human Genetics. 2020 Nov 5;107(5):989-999.
Holzer T, Probst K, Etich J, Auler M, Georgieva VS, Bluhm B, Frie C, Heilig J, Niehoff A, Nüchel J, Plomann M, Seeger JM, Kashkar H, Baris OR, Wiesner RJ, Brachvogel B. Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases. Journal of Cell Biology. 2019 Jun 3;218(6):1853-1870.
Nüchel J, Ghatak S, Zuk AV, Illerhaus A, Mörgelin M, Schönborn K, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, Eckes B. TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators. Autophagy. 2018;14(3):465-486.
Schulz JN, Nüchel J, Niehoff A, Bloch W, Schönborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F, Eckes B. COMP-assisted collagen secretion--a novel intracellular function required for fibrosis. Journal of Cell Science. 2016 Feb 15;129(4):706-16.
Schael S*, Nüchel J*, Müller S, Petermann P, Kormann J, Pérez-Otaño I, Martínez SM, Paulsson M, Plomann M. Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation. Journal of Biological Chemistry. 2013 Mar 29;288(13):9303-12.
(*gleichwertiger Beitrag)