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Publikationen

De La Cruz, N. C., Möckel, M., Wirtz, L., Sunaoglu, K., Malter, W., Zinser, M., and Knebel-Mörsdorf D. Ex vivo infection of human skin with herpes simplex virus 1 reveals mechanical wounds as insufficient entry portals via the skin surface. J Virol. 2021 Aug 11:JVI0133821

De La Cruz, N., and Knebel-Mörsdorf, D. 2021. Endocytic internalization of herpes simplex Virus 1 in human keratinocytes at low temperature. J Virol. 95, e02195-20

Wirtz, L., Möckel M., and Knebel-Mörsdorf, D. 2020. Invasion of herpes simplex virus 1 into murine dermis: The role of nectin-1 and herpesvirus entry mediator as cellular receptors during aging. J. Virol. 94, e02046-19

Möckel, M., Rahn, E., de la Cruz, N., Wirtz, L., van Lent, J.W.M., Pijlman, G.P., and Knebel-Mörsdorf, D. 2019. Herpes simplex virus 1 can enter dynamin 1 and 2 double-knockout fibroblasts. J. Virol. 93, e00704-19

Thier, K., Möckel, M., Palitzsch, K., Döhner, K., Sodeik, B., and Knebel-Mörsdorf, D. 2018.Entry of herpes simplex virus 1 into epidermis and dermal fibroblasts is independent of the scavenger receptor MARCO. J. Virol. 92, e00490-18

Thier, K., Petermann, P., Rahn, E., Rothamel, D., Bloch, W., and Knebel-Mörsdorf, D. 2017. Mechanical barriers restrict invasion of herpes simplex virus 1 into human oral mucosa. J. Virol. 91, e01295-17

Knebel-Mörsdorf, D. 2016. Nectin-1 and HVEM: cellular receptors for HSV-1 in skin. Oncotarget 7(15),19087-8.

Rahn, E., Thier, K., Petermann, P., Rübsam, M., Staeheli, P., Iden, S., Niessen, C.M., and Knebel-Mörsdorf, D. 2017.Epithelial barriers in murine skin during herpes simplex virus 1 infection: The role of tight junction formation. J. Invest. Dermatol. 137, 884-893

Rahn, E., Petermann, P., Thier, K., Bloch, W., Morgner, J., Wickström, S.A., and Knebel-Mörsdorf, D. 2015a. Invasion of herpes simplex virus type 1 into murine epidermis: an ex vivo infection study. J. Invest. Dermatol. 89, 262-274

Rahn, E., Thier. K., Petermann, P., and Knebel-Mörsdorf, D. 2015b. Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1. J Vis Exp. 24, e53046

Petermann, P., Thier, K., Rahn, E., Rixon, F.J., Bloch, W., Özcelik, S., Krummenacher, C., Barron, M.J., Dixon, M.J., Scheu, S., Pfeffer, K., and Knebel-Mörsdorf, D. 2015a. Entry mechanisms of herpes simplex virus 1 into murine epidermis: involvement of nectin-1 and herpesvirus entry mediator as cellular receptors. J. Virol. 89, 262-274

Petermann, P., Rahn, E., Thier, K., Hsu, M.J., Rixon, F.J., Kopp, S.J., and Knebel-Mörsdorf, D. 2015b.  Role of nectin-1 and HVEM as cellular receptors for herpes simplex virus 1 on primary murine dermal fibroblasts. J. Virol. 89, 9407-9416

Mainz, D., Quadt, I., Stranzenbach, A. K., Voss, D., Guarino, L., and Knebel-Mörsdorf, D. 2014. Expression and nuclear localization of the TATA-box-binding protein during baculovirus infection. J. gen. Virol. 95, 1396-1407

Rahn, E., Petermann, P., Hsu, M. J., Frazer, J. R., and Knebel-Mörsdorf, D. 2011. Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent. PLoS ONE 6, e25464

Jaeger, V., Hoppe, S., Petermann, P., Liebig, T., Jansen, M. K., Renné, T., and Knebel-Mörsdorf, D. 2010. Herpes simplex virus type 1 entry into epithelial MDCKII cells: Role of VASP activities. J. gen Virol. 91, 2152-2157

Petermann, P., Haase, I. and Knebel-Mörsdorf, D.  2009 Impact of Rac1 and Cdc42 signaling during early Herpes simplex virus type 1 infection of keratinocytes. J. Virol. 83, 9759-9772

Quadt, I., van Lent, J. W. M., and Knebel-Mörsdorf, D. 2007 Studies of the silencing of baculovirus DNA binding protein. J. Virol. 81, 6122-6127

Hoppe, S., Schelhaas, M., Jaeger, V., Liebig, T., Petermann, P., and Knebel-Mörsdorf, D. 2006 Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells.  J. gen Virol. 87, 3483-3494

Knebel-Mörsdorf, D., Quadt, I., Yi, L., Montier, L., and Guarino, L. 2006 Expression of baculovirus late and very late genes depends on lef-4, a component of the viral RNA polymerase whose guanyltransferase function is essential. J. Virol. 80, 4168-4173

Quadt, I., Günther, A. K., Voß, D., Schelhaas, M., and Knebel-Mörsdorf, D. 2006 TATA-binding protein and TBP-associated factors during herpes simplex virus type 1 infection: Localization at viral DNA replication sites. Virus Res. 115, 207-213

Schelhaas, M., Jansen, M., Haase, I., and Knebel-Mörsdorf, D. 2003 Herpes simplex virus type 1 exhibits a tropism for basal entry in polarized epithelial cells. J. gen Virol. 84, 2473-2484

Quadt, I., Mainz, D., Mans, R. M., Kremer, A., and Knebel-Mörsdorf, D. 2002 Baculovirus infection raises the level of TATA-binding protein that colocalizes with     viral DNA replication sites. J. Virol.76, 11123-11127

Mainz, D., Quadt, I., and Knebel-Mörsdorf, D. 2002 Nuclear IE2 structures are related to viral DNA replication sites during baculovirus infection. J. Virol., 76, 5198-5207

Murges, D., Quadt, I., Schröer, J., and Knebel-Mörsdorf, D. 2001 Dynamic nuclear localization of the baculovirus proteins IE2 and PE38 during the infection cycle: The promyelocytic leukemia protein colocalizes with IE2. Exp.Cell Res. 264, 219-232

Dreschers, S., Roncarati, R., and Knebel-Mörsdorf, D. 2001 The actin rearrangement inducing factor of baculoviruses is tyrosine-phosphorylated and colocalizes to F-actin at the plasma membrane. J. Virol., 75, 3771-3778

Mans, R. M. W., and Knebel-Mörsdorf, D. 1999 Mitochondrial DNA acts as a potential promoter of the baculovirus-induced RNA polymerase. Biological Chemistry, 380, 579-583

Knebel-Mörsdorf, D., Kremer, A., Roncarati, R., Murges, D., Dreschers, S., and  Quadt, I. 1999 The role of early virus genes during the AcMNPV infection cycle. RIKEN review, Vol 22:22-25

Mans, R. M. W., and Knebel-Mörsdorf, D.1998 In vitro transcription of pe38/polyhedrin hybrid promoters reveals sequences essential for recognition by the baculovirus-induced RNA polymerase and for the strength of very late promoters. J. Virol., 72:2991-2998

Kremer, A., and Knebel-Mörsdorf, D. 1998 The early baculovirus he65 promoter: On the mechanism of transcriptional activation by IE1. Virology, 249:336-351

Roncarati, R., and Knebel-Mörsdorf, D. 1997 Identification of the early actin rearrangement inducing factor, arif-1, from     Autographa californica multicapsid nuclear polyhedrosis virus. J. Virol. 71, 7933-7941

Murges, D., Kremer, A., and Knebel-Mörsdorf, D. 1997 Baculovirus transactivator IE1 is functional in mammalian cells. J. gen. Virol. 78, 1507-1510

Knebel-Mörsdorf, D., Flipsen, J.T.M., Roncarati, R., Jahnel, F., Kleefsman, A.W.F., and Vlak, J.M. 1996 Baculovirus infection of Spodoptera exigua larvae: LacZ expression driven by promoters of early genes pe38 and me53 in larval tissue. J. gen. Virol. 77, 815-824

Krappa, R., Roncarati, R., and Knebel-Mörsdorf, D. 1995 Expression of PE38 and IE2, viral members of the C3HC4 finger family, during baculovirus infection: PE38 and IE2 localize to distinct nuclear regions. J.Virol. 69, 5287‑5293

Flipsen, J.T.M., Mans, R.M.W., Knebel-Mörsdorf, D., Kleefsman, A.W.F., and Vlak, J.M. 1995 Deletion of the baculoviral ecdysteroid UDP-glucosyltransferase gene induces early degeneration of malpighian tubules in infected insects. J. Virol. 69, 4529-4532

Knebel-Mörsdorf, D., Kremer, A., and Jahnel, F. 1993 Baculovirus gene ME53, which contains a putative zinc finger motif, is one of the major early-transcribed genes. J. Virol. 67, 753-758

Becker, D., and Knebel-Mörsdorf, D. 1993  Sequence and temporal appearance of the early transcribed baculovirus gene HE65. J. Virol. 67, 5867- 5872

Krappa, R., and Knebel-Mörsdorf, D. 1993 Transcriptional control of early baculovirus genes. In: Virus Strategies. W. Doerfler, P. Böhm (eds.) Verlag Chemie, Weinheim, pp. 335-345

Krappa, R., Behn-Krappa, A., Jahnel, F., Doerfler, W., and Knebel-Mörsdorf, D.  1992 Differential factor binding at the promoter of early baculovirus gene PE38 during viral infection: GATA motif is recognized by an insect protein. J. Virol 66, 3494-3505

Krappa R., and Knebel-Mörsdorf, D. 1991 Identification of the very early transcribed baculovirus gene PE38. J. Virol. 65, 805-812

 

Publikationen vor 1990

Li, J., Happ, B., Schetter, C., Oellig, C., Hauser, C., Kuroda, K., Knebel-Mörsdorf, D., Klenk, H.-D., and Doerfler, W. 1990 The expression of the Autographa californica nuclear polyhedrosis virus genome in insect cells. Veterinary Microbiology 23, 73-78.

Doerfler, W., Hoeveler, A., Weisshaar, B., Dobrzanski, P., Knebel, D., Langner, K.-D., Achten, S., and Müller, U. 1989 Promoter inactivation by sequence-specific methylation and mechanisms of reactivation. Cell Biophysics 15, 21- 27.

Knebel-Mörsdorf, D., Achten, S., Langner, K.-D., Rüger, R., Fleckenstein, B., and Doerfler, W. 1988 Reactivation of the methylation-inhibited late E2A promoter of adenovirus type 2 by a strong enhancer of human cytomegalovirus. Virology 166, 166-174.

Doerfler, W., Weisshaar, B., Hoeveler, A., Knebel, D., Dobrzanski, P., Knust, B., Achten, S., and Hermann, R. 1988 Promoter inhibition by DNA methylation: a reversible signal. Gene 74, 129-133.

Doerfler, W., Langner, K.-D., Knebel, D., Müller, U., Lichtenberg, U., Weisshaar, B., and   Renz, D. 1988 Eukaryotic gene inactivation by sequence-specific promoter methylation and the release of the transcription block. In: Architecture of Eukaryotic Genes. G. Kahl (ed.) Verlag Chemie, Weinheim, pp. 409- 417.

Knebel, D., and Doerfler, W. 1987 Activation of an insect baculovirus promoter in mammalian cells by adenovirus functions. Virus Res. 8, 317-326.

Knebel, D., Langner, K.-D., Hoeveler, A., Lichtenberg, U., Renz, D., and Doerfler, W. 1987 Sequence-specific DNA methylation: promoter inactivation and release of the expression block. In: Tumor Cell Differentiation. Biology and Pharmacology. J. Aarbakke, P.K. Chiang, H.P. Koeffler (eds.) Humana Press, Clifton, N.J., pp. 215-230.

Knebel, D., and Doerfler, W. 1986 N6-methyldeoxyadenosine residues at specific sites decrease the activity of the E1A promoter of adenovirus type 12 DNA. J. Mol. Biol. 189, 371-375.

Doerfler, W., Langner, K.-D., Knebel, D., Lübbert, H., and Knust-Kron, B. 1986  Inactivation of viral promoters by in vitro methylation. Studies on the adenovirus and baculovirus system. Developments in Molecular Virology 8, 193-222.

Doerfler, W., Langner, K.-D., Knebel, D., and Weyer, U. 1986 Regulation of gene expression by site-specific promoter methylations. In: Biological Methylation and Drug Design. R.T. Borchardt, C.R. Creveling, P.M. Ueland (eds.) The Humana Press, Inc., Clifton, N.J., pp. 139- 150.

Knebel, D., Lübbert, H., and Doerfler, W. 1985 The promoter of the late p10 gene in the insect nuclear polyhedrosis virus Autographa californica: activation by viral gene products and sensitivity to DNA methylation. EMBO J. 4, 1301-1306.

Doerfler, W., Langner, K.-D., Knebel, D., Lübbert, H., Kruczek, I., and Weyer, U. 1985 Site-specific methylations inactivate viral promoters. In: Hormones and Cell Regulation. Vol. 9. J.E. Dumont, B. Hamprecht, J. Nunez (eds.) Elsevier Science Publishers, Amsterdam, pp. 47-67.

Doerfler, W., Langner, K.-D., Knebel, D., Weyer, U., Dobrzanski, P., and Knust-Kron, B. 1985 Site-specific promoter methylations and gene inactivation. In: Biochemistry and Biology of DNA Methylation. G.L. Cantoni, A. Razin (eds.) Alan R. Liss, Inc., New York, pp. 133-155.