Publications
Primary data manuscripts
Arad S, Suseendran P, Ravid S, Peleg Y, Ben-Dor S, Fidel E, Olender T, Wang X, Schuldiner M#, Fenech EJ# (2024). A new targeting motif for endoplasmic reticulum surface proteins. bioRxiv.
Fenech EJ#, Kupervaser M, Boshnakovska A, Ravid S, Castro IG, Asraf Y, Callegari S, Lenz C, Rehling P, Schuldiner M# (2024). Profiling the LAM family of contact site tethers provides insights into their regulation and function. bioRxiv.
Fenech EJ*#, Cohen N*, Kupervaser M, Gazi Z, Schuldiner M# (2023). A Toolbox for Systematic Discovery of Stable and Transient Protein Interactors in Baker’s Yeast. Molecular Systems Biology. e11084.
Sathanantham P, Zhao W, He G, Murray A, Fenech E, Diaz A, Schuldiner M, Wang X (2022). A Conserved Viral Amphipathic Helix Governs the Replication Site-Specific Membrane Association. PLOS Pathogens. 18(9): e1010752.
Castro IG, Shortill SP, Dziurdzik SK, Cadou A, Ganesan S, Valenti R, David Y, Davey M, Mattes C, Thomas FB, Avraham RE, Meyer H, Fadel A, Fenech EJ, Ernst R, Zaremberg V, Levine TP, Stefan CJ, Conibear E, Schuldiner M (2022). Systematic Analysis of Membrane Contact Sites in Saccharomyces cerevisiae Uncovers Modulators of Cellular Lipid Distribution. eLife. 11:e74602.
Eisenberg-Bord M, Zung N, Collado J, Drwesh L, Fenech EJ, Fadel A, Dezorella N, Bykov Y, Rapaport D, Fernandez-Busnadiego R, Schuldiner M (2021). Cnm1 Mediates Nucleus-Mitochondria Contact Site Formation in Response to Phospholipid Levels. Journal of Cell Biology. 220:e202104100.
Fenech EJ, Lari F, Charles PD, Fischer R, Laétitia-Thézénas M, Bagola K, Paton AW, Paton JC, Gyrd-Hansen M, Kessler BM, Christianson JC (2020). Interaction Mapping of Endoplasmic Reticulum Ubiquitin Ligases Identifies Modulators of Innate Immune Signalling. eLife. 9:e57307.
Schwaigerlehner L, Mayrhofer P, Diem M, Steinfellner W, Fenech E, Oostenbrink C, Kunert R (2019). Germinality Does Not Necessarily Define mAb Expression and Thermal Stability. Applied Microbiology and Biotechnology. 103: 7505-7518.
Anzilotti C, Swan DJ, Boisson B, Deobagkar-Lele M, Oliveira C, Chabosseau P, Engelhardt KR, Xu X, Chen R, Alvarez L, Berlinguer-Palmini R, Bull KR, Cawthorne E, Cribbs AP, Crockford TL, Dang TS, Fearn A, Fenech EJ, de Jong SJ, Lagerholm BC, Ma CS, Sims D, van den Berg B, Xu Y, Cant AJ, Kleiner G, Leahy TR, de la Morena MT, Puck JM, Shapiro RS, van der Burg M, Chapman JR, Christianson JC, Davies B, McGrath JA, Przyborski S, Koref MS, Tangye SG, Werner A, Rutter GA, Padilla-Parra S, Casanova JL, Cornall RJ, Conley ME, Hambleton S (2019). An Essential Role for the Zn2+ Transporter ZIP7 in B Cell Development. Nature Immunology. 20: 350-361.
Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M (2018). ERAD-dependent Control of the Wnt Secretory Factor Evi. EMBO. 37: e97311.
Schulz J, Avci D, Queisser MA, Gutschmidt A, Dreher LS, Fenech EJ, Volkmar N, Hayashi Y, Hoppe T, Christianson JC (2017). Conserved Cytoplasmic Domains Promote Hrd1 Ubiquitin Ligase Complex Formation for ER-associated Degradation (ERAD). Journal of Cell Science. 130: 3322-3335.
Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ (2015). The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Molecular Cell. 59: 35-49.
Review manuscripts
Fenech EJ, Ben-Dor S, Schuldiner M (2020). Double the Fun, Double the Trouble: Paralogs and Homologs Functioning in the Endoplasmic Reticulum. Annual Reviews of Biochemistry. 89: 637-666.
This review highlights the different functions of genes that appear as homologs in the genome and ways to study this functional diversity. Specifically, I focused on ER-resident proteins, making this the first review to comprehensively address the complexity of studying ER function due to the presence of homologous protein pairs and families. We collaborated with Dr. Shifra Ben-Dor (Life Sciences Core Facility, Weizmann Institute of Science) to collect all S. cerevisiae homologs and their human counterparts, thus creating a rich database available for anyone in the scientific community wishing to explore these gene families. I conceptualised and wrote this review together with Prof. Maya Schuldiner and it will form the groundwork for several future projects in my lab.
News & Views
Volkmar N*, Fenech E*, Christianson JC (2016). New MAPS for Misfolded Proteins. Nature Cell Biology. 18: 724-726.