UNIVERSITY OF COLOGNE

Publications

► Publications at ORCID

Top 5 of all publications

1. Wang, Y.; Li, S.; Mokbel, M. [...] Knorr, R. L.; Fang, X.: Biomolecular condensates mediate bending and scission of endosome membranes. Nature, 2024
   We report that condensates mediate scission of membrane necks without the ESCRT or dynamin protein machineries or ATP consumption.
   ► Press release of the University of Cologne
   ► Research briefing in Nature
2. Kusumaatmaja, H.; May, A. I.; Knorr, R. L.: Intracellular wetting mediates contacts between liquid compartments and membrane-bound organelles. Journal of Cell Biology, 2021
   First review on intracellular capillarity, focussing on membrane-bound organelles.
3. Kusumaatmaja, H.; May, A. I.; Feeney, M.; McKenna, J. F.; Mizushima, N.; Frigerio, L.; Knorr, R. L.: Wetting of phase-separated droplets on plant vacuole membranes leads to a competition between tonoplast budding and nanotube formation. PNAS, 2021
   We show that condensates mediate formation of protein storage vacuoles in plants.
4. Agudo-Canalejo, J.; Schultz, S. W.; Chino, H.; Migliano, S.; Saito, C.; Koyama-Honda, I.; Stenmark, H.; Brech, A.; May, A. I.; Mizushima, N.; Knorr, R. L.: Wetting regulates autophagy of phase separated droplets and the cytosol. Nature, 2021
   First demonstration of intracellular capillary force existing and being physiologically relevant during the formation of autophagosomes.
5. Fujioka, Y; Alam, J. M. D.; Noshiro, D.; Mouri, K.; Ando, T.; Okada, Y.; May, A. I.; Knorr, R. L.; Suzuki, K.; Ohsumi, Y; Noda, N. N.: Phase separation organizes the site of autophagosome formation. Nature, 2020
   We discovered that the yeast autophagy initiation complex is a liquid-like condensate.

Further publications

1. Yang, Z.; Yoshii, S. R.; Sakai, Y; Zhang, J.; Chino, H.; Knorr, R. L.; Mizushima N.: Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates. EMBO J, 2024
2. Sporbeck, K.; Hunter, C.; Takacs, Z.; de Oliveira, A. D.; Maldonado, C. J. P. [...] Knorr, R. L.; Macek, B.; Eskelinen, E. L.; Simonsen, A.; Proikas-Cezanne, T.: The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension. Comm. Biol., 2023
3. Schultz, S. W.; Agudo-Canalejo, J.; Chino, H.; Migliano, S.; Saito, C.; Koyama-Honda, I.; Stenmark, H.; Brech, A.; Mizushima, N.; Knorr, R. L.; May, A. I.: Should I bend or should I grow: The mechanisms of droplet-mediated autophagosome formation. Autophagy, 2021
4. Klionsky, D. J. […] Knorr, R. L. […]: Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy. Autophagy, 2021
5. Vietri, M; Schultz, S. W.; Bellanger, A.; Jones C. M.; Petersen, L. I., Raiborg, C.; Skarpen, E.; Pedurupillay C. R. J.; Kip, E.; Timmer, R.; Jain, A.; Collas, P; Knorr, R. L.; Grellscheid S. N.; Kusumaatmaja, H.; Brech A.; Micci, F.; Stenmark, H.; Campsteijn C.: Unrestrained ESCRT-III drives chromosome fragmentation and micronuclear catastrophe. Nature Cell Biology, 2020
6. Steinkühler, J.; Knorr, R. L.; Zhao, Z.; Bhatia, T.; Bartelt, S. M.; Wegner, S.; Dimova, R.; Lipowsky, R.: Controlled division of cell-sized vesicles by low densities of membrane-bound proteins. Nature Communications, 2020
7. Sakai Y.; Koyama-Honda I.; Tachikawa M.; Knorr, R. L.; Mizushima N.: Modeling membrane morphological change during autophagosome formation. iScience, 2020
8. Zhao, Z.; Roy, D.; Steinkühler, J.; Knorr, R. L.; Robinson, T.; Lipowsky, R.; Dimova, R.: Lipid Nanotubes and Double-Membrane Sheets Induced by Osmotic Deflation of Giant Unilamellar Vesicles Encapsulating Aqueous Two-Phase Solutions. Biophysical Journal, 2020
9. Agudo-Canalejo, J.; Knorr, R. L.: Formation of autophagosomes coincides with a relaxation of membrane curvature. Methods Mol Biol, 2019
10. Petri, J.; Knorr, R. L.: Interactive autophagy: Monitoring a novel form of selective autophagy by macroscopic observations. Methods Mol Biol, 2019
11. Zhao, Z.*; Knorr, R. L.*; Agudo-Canalejo, J.; Robinson, T.; Lipowsky, R.; Dimova, R.: Nanotubes Transform into Double-Membrane Sheets at the Interface between Two Aqueous Polymer Solutions. Biophysical Journal, 2019
12. Steinkühler, J.; Bartelt, S. M.; Wegner, S.; Knorr, R. L.; Dimova, R.; Lipowsky, R.: Budding and Fission of Vesicles by Control of Membrane Spontaneous Curvature. Biophysical Journal, 2019
13. Knorr, R. L.; Steinkühler, J.; Dimova, R.: Micron-sized domains in quasi single-component giant vesicles. Biochimica et Biophysica Acta-Biomembranes, 2018
14. Avalos-Padilla, Y.; Knorr, R. L.; Javier-Reyna, R.; García-Rivera, G.; Lipowsky, R.; Dimova, R.; Orozco, E.: The conserved ESCRT III machinery participates in the phagocytosis of Entamoeba histolytica. Frontiers in Cellular and Infection Microbiology, 2018
15. Steinkühler, J.; De Tillieux, P.; Knorr, R. L.; Lipowsky, R.; Dimova, R.: Charged giant unilamellar vesicles prepared by electroformation exhibit nanotubes and transbilayer lipid asymmetry. Scientific Reports, 2018
16. Zhao, Z.; Roy, D.; Steinkühler, J.; Robinson, T.; Knorr, R. L.; Lipowsky, R.; Dimova, R.: Super resolution imaging of highly curved membrane structures in giant unilamellar vesicles encapsulating polymer solutions. Biophysical Journal, 2018
17. Knorr, R. L.; Mizushima, N.; Dimova, R.: Fusion and scission of membranes: Ubiquitous topological transformations in cells. Traffic, 2017
18. Wijekoon, C. J. K.; Udagedara, S. R.; Knorr, R. L.; Dimova, R.; Wedd, A. G.; Xiao, Z.: Copper ATPase CopA from Escherichia coli: Quantitative Correlation between ATPase Activity and Vectorial Copper Transport. JACS, 2017
19. Lira, R. B.; Steinkühler, J.; Knorr, R. L.; Dimova, R.; Riske, K. A.: Posing for a picture: vesicle immobilization in agarose gel. Scientific Reports, 2016
20. Knorr, R. L.; Lipowsky, R.; Dimova, R.: Autophagosome closure requires membrane scission. Autophagy, 2015
21. Knorr, R. L.; Nakatogawa, H.; Ohsumi, Y.; Lipowsky, R.; Baumgart, T.; Dimova, R.: Membrane Morphology Is Actively Transformed by Covalent Binding of the Protein Atg8 to PE-Lipids. PLoS One, 2014
22. Knorr, R. L.; Dimova, R.; Lipowsky, R.: Curvature of Double-Membrane Organelles Generated by Changes in Membrane Size and Composition. PLoS One, 2012
23. Salipante, P. F.; Knorr, R. L.; Dimova, R.; Vlahovska, P. M.: Electrodeformation method for measuring the capacitance of bilayer membranes. Soft Matter, 2012
24. Vequi-Suplicy, C. C.; Riske, K. A.; Knorr, R. L.; Dimova, R.: Vesicles with charged domains. Biochimica et Biophysica Acta-Biomembranes, 2010
25. Gracià, R. S.; Bezlyepkina, N.; Knorr, R. L.; Lipowsky, R.; Dimova, R.: Effect of cholesterol on the rigidity of saturated and unsaturated membranes: fluctuation and electrodeformation analysis of giant vesicles. Soft Matter, 2010
26. Knorr, R. L.; Staykova, M.; Gracià, R. S.; Dimova, R.: Wrinkling and electroporation of giant vesicles in the gel phase. Soft Matter, 2010
27. Dimova, R.; Bezlyepkina, N.; Jordo, M. D.; Knorr, R. L.; Riske, K. A.; Staykova, M.; Vlahovska, P. M.; Yamamoto, T.; Yang, P.; Lipowsky, R.: Vesicles in electric fields: Some novel aspects of membrane behavior. Soft Matter, 2009
28. Riske, K. A.; Knorr, R. L.; Dimova, R.: Bursting of charged multicomponent vesicles subjected to electric pulses. Soft Matter, 2009
29. Riske, K. A.; Knorr, R. L.; Dimova, R.: Bursting Instability of Charged Multicomponent Vesicles Subjected to Electric Pulses. Biophysical Journal, 2009
30. Dimova, R.; Riske, K. A.; Aranda, S.; Bezlyepkina, N.; Knorr, R. L.; Lipowsky, R.: Giant vesicles in electric fields. Soft Matter, 2007
31. Knorr, R.; Hamburger, M.: Quantitative Analysis of Anti-inflammatory and Radical Scavenging Triterpenoid Esters in Evening Primrose Oil. Journal of Agricultural and Food Chemistry, 2004